A study published in The Lancet journal suggests that taking 600mg of aspirin a day may lead to lower levels of colorectal cancer in people with Lynch Syndrome. This study used a high dosage of aspirin and recommended that further study was needed to determine the best dosage. Use of all medications should be discussed with your healthcare provider and your Lynch Syndrome specialist. Aspirin use has been associated with gastric bleeding and allergies. Aspirin can affect the ability of your blood to clot and can lead to excessive bleeding. So make sure you discuss use of aspirin with your healthcare provider before taking it. For additional information go to
References
Ask the cancer genetics team: Lynch syndrome and aspirin, (n. d.) Dana Farber Health Library. Retrieved from http://www.dana-farber.org/Health-Library/Ask-the-cancer-genetics-team--Lynch-syndrome-and-aspirin.aspx
Burn, J, Gerdes, A., Macrae, F. Mecklin, J., Moeslein, G., Olschwang, S… Bishop, D. T. (2011). Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. The Lancet, 378, (9809), 2081–2087. doi: 10.1016/S0140-6736(11)61049-0
Can Lifestyle Decisions Affect the Risk Of Familial Breast Cancer?
We are by bombarded by media messages that admonish us to make healthy lifestyle choices. Eat right! Watch your weight! Exercise! Don't drink to excess! But can lifestyle affect the risk of breast cancer when you have a genetic predisposition as in Lynch Syndrome? A study published in Breast Cancer Research suggests that it may make a difference. Researchers found that participating in moderately vigorous exercise for 20 minutes 5 times a week, keeping your body mass index under 24.9, and limiting alcohol consumption to no more than 7 drinks a week reduces breast cancer risk by 25% for women with and without familial breast cancer predisposition.
References
Gramling, R., Lash, T. L., Rothman, K. J., Cabral, H. J., Stillmann, R., Roberts, M., Stephanick, M. L., ... Eaton, C. B. (2010). Family history of later-onset breast cancer, breast healthy behavior, and invasive breast cancer among post menopausal women: A cohort study. Breast Cancer Research, 12 (5). Retrieved from http://breast-cancer-research.com/content/12/5/r82. doi:10.1186/bcr2727 Special Risk In Families of Jewish Ashkenazi Heritage
If your families ethnicity is Jewish of Ashkenazi descent your healthcare provider should be informed. A recent study found that families with Ashkenazi heritage have a higher risk of colorectal cancer and endometrial cancer. Specialized testing is recommended for the MSH2 A636P mutation according to a study published 2011 in the journal of Gastroenterology.
References
Mukherjee B., Rennert, G.,Ahn, J., Dishon, S., Lejbkowicz, F., Rennert,
H. S., Stacey Shiovitz… Gruber, S. B. (2011). High Risk of Colorectal and
Endometrial Cancer in Ashkenazi Families With the MSH2 A636P Founder Mutation.
Gastroenterology, 140, (7), 1919–1926. doi: 10.1053/j.gastro.2011.012.07
When to Test Children for Lynch Syndrome
| Microsoft Office 2011 |
The decision to test your child for Lynch
Syndrome is a very personal decision. A genetic counselor can provide you with
information regarding the probability of Lynch cancers developing in minors but
the decision to go forward with genetic testing rests solely with parents. The
American Society of Clinical Oncology (ASCO) recognizes that the decision to
test or not to test is a parental right and suggests that parents ask
themselves two questions. Is there a significant chance that cancer will
develop before the child reaches the age of consent? If the genetic test is
positive, is a strategy to reduce the risk of cancer available? If the answer
to the questions is no, the ASCO recommends parents wait until the child is old
enough to make an informed decision.
If you would like
more information on this topic click on the link below to access the Dana
Farber Cancer Institutes’ Health Library and read “Ask the cancer genetic team:
When to test children” page.
http://www.dana-farber.org/Health-Library/Ask-the-cancer-genetics-team--when-to-test-children.aspx
References
American Society
of Clinical Oncology Policy Statement Update: Genetic Testing for Cancer
Susceptibility. (2003). Journal of
Clinical Oncology, 21, (12) 2397–2406. doi: 10.1200/jco.2003.03.189
Creating a Family Health History
The Surgeon
General has developed an online tool to help you create a family health history
called “My Family Health Portrait.” The office of the Surgeon General suggests
that it takes 15-20 minutes to create a basic family health history using the
tool. The tool puts together the information that you enter and develops a
family tree diagram. The diagram can be
printed so that you can share with other family members and your healthcare
practitioner. The website does not store your information nor allow access
anyone else access to the data. Click on the link below to be directed to the
Surgeon Generals family history website.
References
U.S. Department of Health & Human Services. (n. d.). My Family Health Portrait. Retrieved from
https://familyhistory.hhs.gov/fhh-web/familyHistory/start.action
The Link between Atypical Skin Tumors and Lynch Syndrome
Muir-Torre is a genetic
condition that is associated with tumors in the oil glands of skin and has also been
linked with with gastrointestinal cancers. Studies now suggest that Muir-Torre is a form of
Lynch Syndrome. Individuals who develop tumors called sebaceous adenomas,
sebaceous adenocarcinomas or keratoacanthomas should be tested for Lynch
Syndrome according to recent studies. If you or a family member is diagnosed
with a tumor of the oil glands ask your healthcare provider about seeing a
genetic counselor to discuss genetic testing.
Kleinerman, R.,
Marino, J., & Loucas, E. (2012). Muir-Torre Syndrome / Turcot Syndrome
overlap? A patient with sebaceous carcinoma, colon cancer, and a malignant
astrocytoma. Dermatology Online Journal, 18(5). Retrieved from: http://escholarship.org/uc/item/04p4s7fmSkin
Conditions Linked to Lynch Syndrome
South, C. D., Hampel,
H., Comeras, I, Westman, J.A., Frankel, W. L., & de la Chapelle, A. (2008).
The frequency of Muir-Torre Syndrome
among Lynch Syndrome families. Journal
of the National Cancer Institute, 100 (4), 277– 281.Retrieved from http://jnci.oxfordjournals.org/content/early/2008/02/12/jnci.djm291.full.pdf+html.doi:10.1093/jnci/djm291
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